Joe De Santis (15 Mei 1909 – 30 Augustus 1989) was 'n Amerikaanse akteur. Hy was bekend vir sy rolle in die rolprente Al Capone (1959) en Beau Geste (1966), en in die televisiereekse Playhouse 90 (1956) en 77 Sunset Strip (1958).
- 1959: Al Capone
- 1961: A Cold Wind in August
- 1966: Beau Geste
- 1966: And Now Miguel
- 1987: How Rare a Possession: The Book of Mormon
- 1949: Photocrime
- 1951: Crime Photographer
- 1956: Playhouse 90
- 1958: 77 Sunset Strip
- 1959: The Man from Blackhawk
- 1959: Doctor Mike
- 1960: Unsolved
- 1975: Katherine
