Abakavir/lamivudien/sidovudien

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Abakavir/lamivudien/sidovudien (INN, handelsnaam Trizivir) is 'n geneesmiddelbehandeling vir MIV-infeksie.^[1] Dit is 'n vastedosis-kombinasieterapie van drie trutranskriptase inhibeerders gepatenteer deur GlaxoSmithKline en nou deur sy gesamentlike onderneming met Pfizer, ViiV Healthcare bemark:^[2]

abakavir (ABC)
lamivudien (3TC)
sidovudien (AZT)

Dit word gebruik in die behandeling van MIV/Vigs.^[3] Vir hierdie doel, is die kombinasie baie nuttig in swanger vroue om die risiko van moeder-na-kind-oordrag te verminder.^[4] Die kombinasie van middels help om MIV se weerstand (deur mutasie) tot die individuele middels te verminder. Van die drie, het AZT en ABC se patentreg reeds verval in die Verenigde State van Amerika. In Desember 2013 het Lupin Beperk begin met 'n generiese weergawe van Trizivir.^[5]^[6]

Verwysings

↑ Opravil, Milos; Hirschel, Bernard; Lazzarin, Adriano; Furrer, Hansjakob; Chave, Jean‐Philippe; Yerly, Sabine; Bisset, Leslie R.; Fischer, Marek; Vernazza, Pietro; Bernasconi, Enos; Battegay, Manuel; Ledergerber, Bruno; Günthard, Huldrych; Howe, Colin; Weber, Rainer; Perrin, Luc (Mei 2002). "A Randomized Trial of Simplified Maintenance Therapy with Abacavir, Lamivudine, and Zidovudine in Human Immunodeficiency Virus Infection". The Journal of Infectious Diseases. 185 (9): 1251–1260. doi:10.1086/340312.
↑ InPharm.com: GlaxoSmithKline-Pfizer launch HIV joint venture Geargiveer 4 Januarie 2012 op Wayback Machine
↑ Drugs.com: Trizivir
↑ Horvath, Tara; Madi, Banyana C; Iuppa, Irene M; Kennedy, Gail E; Rutherford, George W; Read, Jennifer S.; Horvath, Tara (2009). "Interventions for preventing late postnatal mother-to-child transmission of HIV" (1): CD006734. doi:10.1002/14651858.CD006734.pub2. PMID 19160297. {{cite journal}}: Cite journal requires |journal= (hulp)
↑ Monthly Prescribing Reference (MPR): [1]
↑ Lupin Pharma: [2]

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[1] Opravil, Milos; Hirschel, Bernard; Lazzarin, Adriano; Furrer, Hansjakob; Chave, Jean‐Philippe; Yerly, Sabine; Bisset, Leslie R.; Fischer, Marek; Vernazza, Pietro; Bernasconi, Enos; Battegay, Manuel; Ledergerber, Bruno; Günthard, Huldrych; Howe, Colin; Weber, Rainer; Perrin, Luc (Mei 2002). "A Randomized Trial of Simplified Maintenance Therapy with Abacavir, Lamivudine, and Zidovudine in Human Immunodeficiency Virus Infection". The Journal of Infectious Diseases. 185 (9): 1251–1260. doi:10.1086/340312.

[2] InPharm.com: GlaxoSmithKline-Pfizer launch HIV joint venture Geargiveer 4 Januarie 2012 op Wayback Machine

[3] Drugs.com: Trizivir

[HorvathMadi2009-4] Horvath, Tara; Madi, Banyana C; Iuppa, Irene M; Kennedy, Gail E; Rutherford, George W; Read, Jennifer S.; Horvath, Tara (2009). "Interventions for preventing late postnatal mother-to-child transmission of HIV" (1): CD006734. doi:10.1002/14651858.CD006734.pub2. PMID 19160297. {{cite journal}}: Cite journal requires |journal= (hulp)

[5] Monthly Prescribing Reference (MPR): [1]

[6] Lupin Pharma: [2]

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