Gebruiker:Wyatt Tyrone Smith/Sandput3: Verskil tussen weergawes

Content deleted Content added
Besig
Klaar
Lyn 57:
Gorski se navorsing is gebruik in terapeutiese anti[[kanker]]-navorsing om die terapeutiese effekte van ioniserende bestraling te verbeter{{R|Kerbel2002}} en om die potensiaal van kombinasieterapieë te bepaal om die dosisse in toksiese konvensionele behandelings te verlaag,{{R|Dvorak2002}} terwyl tumorregering gehandhaaf word.{{R|Klement2000}}
 
Gorski se werk met Helena Mauceri en ander, gepubliseer in die faktydskrif ''Nature'',{{R|Mauceri1998}} het gelei tot die ondersoek na die selektiewe vernietiging van kankergewasselle "sonder groot sistemiese newe-effekte."{{R|Semenza1999}}
 
Sy artikel met Yun Chen het die gebruik van mikro[[RNS]] om die groei van nuwe bloedvate te reguleer ondersoek{{R|Chen2008}} en het gelei tot navorsing oor die gebruik van mikroRNS om die ontwikkeling van bloedvate te reguleer en sodoende die groei van kankergewasse te beperk.{{R|Fish2008}}
 
Gorski se werk saam met Helena Mauceri en ander, gepubliseer in Nature as "Gekombineerde effekte van angiostatien en ioniserende bestraling in antitumor-terapie" bestudeer die "gekombineerde effekte van angiostatien" ('n proteïen wat in verskillende diersoorte voorkom) "en ioniserende bestraling in antitumor-terapie "[21] het gelei tot ondersoek na die selektiewe vernietiging van gewasselle, wat volgens 'n studie deur Gregg L. Semenza (met verwysing na Mauceri en ander)" meer hipoksies as normale selle is ", wat dit moontlik maak om 'tumorzelle dood te maak sonder groot sistemiese newe -effekte. "[22]
 
Sy artikel met Yun Chen "Regulering van angiogenese deur middel van 'n mikroRNA (miR-130a) wat antiangiogeniese homeobox-gene GAX en HOXA5 afreguleer", het ondersoek ingestel na die gebruik van mikroRNA om angiogenese te reguleer [23], het gelei tot navorsing deur Jason E. Fish se groep by die Universiteit van Kalifornië, San Francisco, in die gebruik van mikroRNA om die ontwikkeling van bloedvate te reguleer en sodoende die groei van gewasse te beperk. Met verwysing na Chen en Gorski se navorsing, het Fish geskryf dat "verskeie mikroRNA's in groot mate die in vitro endoteelselle se gedrag reguleer, insluitend proliferasie, migrasie en die vermoë om kapillêre netwerke te vorm", en wou die in vivo -funksionaliteit van 'n spesifieke stel mikroRNA's beskryf en hul teikens; die groep kon 'n spesifieke mikro-RNA (miR-126) isoleer as die mees verrykte in endoteelselle. [24]
 
== Skeptisisme van alternatiewe medisyne ==
Line 102 ⟶ 100:
 
<ref name="cancer grad prog">{{cite web |work= Cancer Biology Graduate Program |title= David H. Gorski |url= http://cancerbiologyprogram.med.wayne.edu/faculty/gorski.php |publisher=Wayne State University School of Medicine |year= 2013 |access-date=9 Augustus 2021 |language=en |archive-url= https://web.archive.org/web/20120722100844/http://cancerbiologyprogram.med.wayne.edu/faculty/gorski.php |archive-date=22 Julie 2012 |url-status=dead}}</ref>
 
<ref name="Chen2008">{{Cite journal |doi= 10.1182/blood-2007-07-104133 |issn=0006-4971 |volume= 111 |issue= 3 |pages= 1217–1226 |last1= Chen |first1= Yun |first2= David H. |last2= Gorski |title= Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 |journal=Blood |publisher=American Society of Hematology |date= 1 Februarie 2008 |pmid=17957028 |pmc= 2214763 |language=en}}</ref>
 
<ref name="Coulter">{{cite web |last= Miller |first= Henry I. |title= Can tiny amounts of poison actually be good for you? |url= https://www.forbes.com/sites/henrymiller/2011/12/21/can-tiny-amounts-of-poison-actually-be-good-for-you/ |date= 21 Desember 2011 |work= Forbes.com |publisher=Forbes Media |access-date=11 Augustus 2021 |language=en}}</ref>
Lyn 110:
 
<ref name="Dvorak2002">{{Cite journal |doi= 10.1200/JCO.2002.10.088 |issn=1527-7755 |volume= 20 |issue= 21 |pages= 4368–4380 |last= Dvorak |first= Harold F. |title= Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy |journal=Journal of Clinical Oncology |date= 1 November 2002 |publisher=American Society of Clinical Oncology |pmid= 12409337 |language=en}}</ref>
 
<ref name="Fish2008">{{Cite journal |doi= 10.1016/j.devcel.2008.07.008 |issn=1534-5807 |volume= 15 |issue= 2 |pages= 272–284 |last1= Fish |first1= Jason E. |first2= Massimo M. |last2= Santoro |first3= Sarah U. |last3= Morton |first4= Sangho |last4= Yu |first5= Ru-Fang |last5= Yeh |first6= Joshua D. |last6= Wythe |first7= Kathryn N. |last7= Ivey |first8= Benoit G. |last8= Bruneau |first9= Didier Y.R. |last9= Stainier |first10= Deepak |last10= Srivastava |display-authors=4 | title= miR-126 Regulates Angiogenic Signaling and Vascular Integrity |journal= Developmental Cell |publisher=Cell Press | date=12 Augustus 2008 |pmid=18694566 | pmc= 2604134 |language=en}}</ref>
 
<ref name="Fisher">{{cite journal | date=11 Junie 2007 | first1=Michele | last1=Fisher | url=http://www.umdnj.edu/about/news_events/releases/07/r061107_NJ_SurgicalOncologist_ReceivesPrestigiousAward_atInternationalConference.htm | title=New Jersey surgical oncologist receives prestigious award at international conference | publisher=University of Medicine and Dentistry of New Jersey | archive-url=https://web.archive.org/web/20130205153112/http://www.umdnj.edu/about/news_events/releases/07/r061107_NJ_SurgicalOncologist_ReceivesPrestigiousAward_atInternationalConference.htm | archive-date=5 Februarie 2013 |language=en}}</ref>
Line 135 ⟶ 137:
<ref name="KarmanosTeam">{{cite web |url=http://www.karmanos.org/cancer-care/teams/Breast-Team |title=Breast Cancer Program |year=2013 |publisher=Barbara Ann Kamanos Cancer Institute, Wayne State University |access-date=9 Augustus 2021 |language=en |url-status=dead |archive-url=https://web.archive.org/web/20190108030724/https://www.karmanos.org/cancer-care/teams/Breast-Team |archive-date=9 Oktober 2019}}</ref>
 
<ref name="Kerbel2002">{{Cite journal |doi= 10.1038/nrc905 |issn=1474-175X |volume= 2 |issue= 10 |pages= 727–739 |last1= Kerbel |first1= Robert |first2= Judah |last2= Folkman |author-link2= Judah Folkman |title= Clinical translation of angiogenesis inhibitors |journal=Nature Reviews Cancer |date= Oktober 2002 |pmid= 12360276 |s2cid= 14513505 |language=en}}</ref>
 
<ref name="Klement2000">{{Cite journal |issn=0021-9738 |volume= 105 |issue= 8 |pages= R15–R24 |last1= Klement |first1= Giannoula |first2= Sylvain |last2= Baruchel |first3= Janusz |last3= Rak |first4= Shan |last4= Man |first5= Katherine |last5= Clark |first6= Daniel J. |last6= Hicklin |first7= Peter |last7= Bohlen |first8= Robert S. |last8= Kerbel |display-authors=4 |title= Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity |journal=Journal of Clinical Investigation |publisher=American Society for Clinical Investigation | date= 15 April 2000 |pmid=10772661 |doi= 10.1172/JCI8829| pmc= 517491 |language=en}}</ref>
Line 144 ⟶ 146:
 
<ref name="Maher">{{cite web |last1=Fahey |first1=Jonathan |last2=Whelan |first2=David |title=In Pictures: Celebs Who Take On Science |url=https://www.forbes.com/2010/01/14/science-jenny-mccarthy-business-healthcare-hollywood-autism_slide_8.html |page=8 |date=14 Januarie 2010 |work=Forbes.com |publisher=Forbes Media |access-date=11 Augustus 2021 |language=en}}</ref>
 
<ref name="Mauceri1998">{{cite journal |last1= Mauceri |first1= Helena J. |last2= Hanna |first2= Nader N. |last3= Beckett |first3= Michael A. |last4= Gorski |first4= David H. |last5= Staba |first5= Mary-Jane |last6= Stellato |first6= Kerri Anne |last7= Bigelow |first7= Kevin |last8= Heiman |first8= Ruth |last9= Gately |first9= Stephen |last10= Dhanabal |first10= Mohanraj |last11= Soff |first11= Gerald A. |last12= Sukhatme |first12= Vikas P. |last13= Kufe |first13= Donald W. |last14= Weichselbaum |first14= Ralph R. |display-authors=4 |title= Combined effects of angiostatin and ionizing radiation in antitumour therapy |journal=Nature |volume= 394 |date= 16 Julie 1998 |pages= 287–291 |doi= 10.1038/28412 |pmid= 9685160 |issue=6690 |bibcode= 1998Natur.394..287M |s2cid= 4391890 |language=en}}</ref>
 
<ref name="mcgill">{{cite web |url=https://www.mcgill.ca/science/events/trottier-symposium/2010/october18 |title=Drs. Ben Goldacre, David Gorski and Michael Shermer on the threat of pseudoscience |date=18 Oktober 2010 |work=McGill University Faculty of Science |access-date=11 Augustus 2021 |language=en}}</ref>
Line 164 ⟶ 168:
 
<ref name="science guides">{{cite web |author=JREF Staff |title=JREF publishes three volumes on science-based medicine |url=http://archive.randi.org/site/index.php/jref-news/2023-jref-publishes-three-volumes-on-science-based-medicine.html |work=James Randi Education Foundation |access-date=11 Augustus 2021 |language=en}}</ref>
 
<ref name="Semenza1999">{{Cite journal |doi= 10.1146/annurev.cellbio.15.1.551 |volume= 15 |issue= 1 |pages= 551–578 |last= Semenza |first= Gregg L. |title= Regulation of Mammalian O2 Homeostasis by Hypoxia-Inducible Factor 1 |journal=Annual Review of Cell and Developmental Biology |year= 1999 |pmid= 10611972 |issn=1081-0706 |url= http://rsp.ima-press.net/rsp/article/view/2307 |language=en}}</ref>
 
<ref name="study">{{cite web |last= Khorana |first= Alok |title= Alternative medicine and trials of dubious ethicality |url= http://boards.medscape.com/forums/?128@@.29f63208!comment=1 |work= OncNotes |publisher=Medscape |date= 16 September 2009 |access-date=11 Augustus 2021 |language=en}}</ref>